GC (Vitamin D Binding Protein) rs2282679

Gene function:
The GC gene (Group-specific Component) encodes the vitamin D binding protein (VDBP), which transports and distributes vitamin D throughout the body. Individuals who are homozygous or heterozygous have lower circulating 25-hydroxy vitamin D3 than subjects with normal genotypes. These individuals are more prone to deficiency and may require higher dietary intake to maintain optimal levels.

Effect of the SNP:
Both +/+ and +/- genotypes are associated with lower circulating vitamin D levels.

Specialized nutritional support*:
Vitamin D3

The multivitamin is optional foundational support

BCMO1 (ß-Carotene 15,15’-monooxygenase 1) R267S

Gene function:
BCMO1 encodes an enzyme in the small intestinal mucosa that catalyzes a critical step in the conversion of beta-carotene to vitamin A. Vitamin A is essential for immune function, vision, growth, reproductive function and cellular health.*

Effect of the SNP:
The R267S and A379V polymorphisms reduce the activity of the BCMO1 enzyme, which converts dietary beta-carotene to active vitamin A. Human studies have associated these SNPs with lower circulating vitamin A levels, with and without beta-carotene supplementation. Female volunteers with 379V exhibited a 32% reduction in the ability to generate vitamin A from dietary beta-carotene. Subjects who were hetero- or homozygous for both R267S and A379V had a 69% reduction in conversion efficiency.

Specialized nutritional support*:
Preformed vitamin A (retinol)

The multivitamin is optional foundational support

BCMO1 (ß-Carotene 15,15’-monooxygenase 1) A379V

Gene function:
BCMO1 encodes an enzyme in the small intestinal mucosa that catalyzes a critical step in the conversion of beta-carotene to vitamin A. Vitamin A is essential for immune function, vision, growth, reproductive function and cellular health.*

Effect of the SNP:
The R267S and A379V polymorphisms reduce the activity of the BCMO1 enzyme, which converts dietary beta-carotene to active vitamin A. Human studies have associated these SNPs with lower circulating vitamin A levels, with and without beta-carotene supplementation. Female volunteers with 379V exhibited a 32% reduction in the ability to generate vitamin A from dietary beta-carotene. Subjects who were hetero- or homozygous for both R267S and A379V had a 69% reduction in conversion efficiency.

Specialized nutritional support*:
Preformed vitamin A (retinol)

The multivitamin is optional foundational support
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Sample Report

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