Suggested tests for assessment and monitoring

Gene and SNP Nutritional support Suggested assessment method(s)
ADIPOQ (rs17366568)


Metabolic Xtra

Serum adiponectin
APOA2 (rs5082) PureLean® Protocol Anthropometric (body weight and body composition)
BCMO1 (R267S and/or A379V) Vitamin A Serum retinol and beta carotene are useful as vitamin A status may be low and serum beta-carotene levels may be elevated due to poor conversion of dietary retinol.
CBS (C699T) Vitamin B6 (P5P) Xanthurenate is a functional marker of vitamin B6 status. Serum homocysteine may also be informative, as CBS activity is inversely associated with homocysteine levels.
COMT (Val/Met 158) Diindolylmethane (DIM), magnesium, lithium, SAMe Estrogen methylation ratio 2OHE1:2OMeE1) indicates how effectively a patient methylates 2-hydroxyestrone to 2-methoxyestrone and is suggested when DIM is used. No definitive test is available for magnesium, lithium or SAMe.
FADS1 (rs174547) EPA/DHA Essential and Metabolic Fatty Acids Analysis RBC (Genova)
FTO (rs9939609)

PureLean Ultra


PureLean® Protocol

Anthropometric (body weight and body composition)
GC (rs2282679) Vitamin D3 25-hydroxy vitamin D3 is an indicator of overall vitamin D status.
MTHFR (C677T and/or A1298C) Folate (5-MTHF) Serum homocysteine is useful as an indicator of overall methylation competence and a nonspecific test for folate, B12 and B6 monitoring. Formiminoglutamate (FIGLU) is a functional marker of folate status.
MTR (A2756G) Vitamin B12 Methylmalonate (MMA) is a marker of vitamin B12 status. In contrast to serum B12, MMA reflects intracellular levels of the vitamin.
TCN2 (C776G) Vitamin B12 Holo-transcobalamin levels reflect the fraction of circulating vitamin B12 that is bound to transcobalamin and is therefore available to cells. Methylmalonate (MMA) may also be used.