BDNF (Brain-Derived Neurotrophic Factor) rs6265

Gene function:
Brain-derived neurotrophic factor (BDNF) is a neuroprotective protein that supports mood, memory and long-term brain health. It plays vital roles in the survival, maintenance and growth of many types of neurons and is expressed in the hippocampus, hypothalamus, and cerebral cortex. These areas of the brain mediate the formation and retrieval of memories. Aging, poor diet, stress, lack of physical activity and genetic polymorphisms are associated with decreased BDNF levels.

Effect of the SNP:
Carriers of the Met (+) allele are more likely to have lower BDNF production than individuals with the Val (-) allele.

Specialized nutritional support:
Exercise is one of the most effective lifestyle strategies to increase and maintain the body’s ability to make BDNF. Magnesium and trace minerals such as zinc also play a role in BDNF production. Polyphenols from fruits, tea and turmeric are also beneficial.

Nutritional assessment considerations:
Serum zinc or alkaline phosphatase are effective methods to assess and monitor zinc status. Magnesium status may be assessed through hair analysis and RBC magnesium, respectively.

The multivitamin is optional foundational support

DRD2 (Dopamine D2 Receptor) rs6277

Gene function:
The DRD2 gene encodes the D2 subtype of the dopamine receptor, which plays critical roles in neurotransmission. DRD2 recognizes dopamine produced by other neurons and orchestrates many of its positive effects on cognition.

Effect of the SNP:
This SNP alters dopamine signaling in areas of the brain that orchestrate cognitive functions. Studies have associated the C allele with reduced performance on tests of executive function and working memory.

Specialized nutritional support:
L-tyrosine is a precursor of L-DOPA, which is converted to dopamine. Zinc, folate and vitamin B6 serve as cofactors in this pathway.

Nutritional assessment considerations:
This SNP does not affect micronutrient levels, but dopamine neurotransmission is dependent on adequate zinc, folate and vitamin B6 status. Consider assessing these nutrients.

The multivitamin is optional foundational support

TPH2(Tryptophan Hydroxylase 2) rs4570625

Gene function:
TPH2 is an enzyme in the brain that converts the amino acid, tryptophan, to 5-HTP, the precursor of serotonin. Serotonin helps to maintain a positive emotional state and promotes relaxation and healthy eating behavior.

Effect of the SNP:
The T allele is associated with reduced enzyme activity. In a 2012 meta-analysis, individuals with the T allele were more likely to require medical support for mood than those with the G allele.

Specialized nutritional support:
5-HTP is the activated serotonin precursor. Consider 5-HTP supplementation if mood and emotional well-being are important clinical objectives.

Nutritional assessment considerations:
Serotonin biosynthesis requires vitamin B6, folate, magnesium, zinc and vitamin D. Consider assessing levels of these nutrients. Optimizing levels of these nutrients may additionally support mood.*

The multivitamin is optional foundational support
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Sample Report

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